Scientist II, Assay Development and Screening

Company: 1910genetics
Location: Boston
Posted on: April 3, 2025

Job Description:

Scientist II, Assay Development and Screening1910 Genetics is the only company that has built a synergistic, dual-purpose small and large molecule platform that integrates artificial intelligence (AI), computation, and biological automation to design drug-like molecules better, faster, and cheaper than traditional approaches. Based in the Seaport District of Boston, 1910 Genetics is a Series A stage biotechnology startup that was founded in 2018 and is backed by prestigious investors, including M12-Microsoft's Venture Fund, Sam Altman - the CEO of OpenAI (makers of ChatGPT), Playground Global, Y Combinator, New Ventures Funds (Scientia Ventures), and many others.At 1910 Genetics, we first established an understanding of the molecular basis of disease to the granularity at which the world understands sickle cell anemia. This understanding centers biology as our North Star and drives our integration of artificial intelligence (AI), computation, and biological automation to accelerate the design of small molecule and protein therapeutics.Recent advances in computational technologies have placed historically "undruggable" targets within therapeutic reach. But at 1910 Genetics, we often say "Biology is King," meaning that computational technologies are only impactful in drug discovery when driven by experimental biology. Our platforms' scale and breadth empower us to be therapeutic area-agnostic with programs ranging from neuroscience and immunology to infectious disease and oncology, to name a few.COMPANY OVERVIEW:Computation is revolutionizing drug discovery. Advances in big chemical data, massive computing power, artificial intelligence, and molecular dynamics simulation are changing the way we develop new drugs. At 1910 Genetics, we put computation at the heart of drug discovery, blending expertise in computational chemistry, structural biology, pharmacology, genetics, data science, and software engineering to develop drugs for previously undruggable targets. To assist with our goal of expediting drug discovery, 1910 Genetics seeks a Scientist II, Assay Development and Screening, for an impactful position within our Biology Department. This individual would own the implementation and execution of in vitro assay development and screening strategies, assist in lab automation, manage the lab operations and activities of junior level scientists and CROs, and contribute to progressing lead compounds through our drug discovery process.In this role you will---

• Contribute to project progression by using biochemical and cell-based screening and profiling assays to identify small molecules with characteristics meeting the Target Product Profile (TPP).
• Develop, evaluate, optimize and implement biochemical and cell-based assays that are either novel, commercially available, or from publications, depending on the needs of the project.
• Work independently liaising closely with colleagues within the project team and across functional groups, including AI and Chemistry, to ensure deadlines are met.
• Utilize your expertise in a variety of biochemical and cell-based assay formats to implement screening workflows in a timely and efficient manner. Prior experience with HPLC will be a plus.
• Maintain clear and efficient communication.
• Supervise and manage 1-3 Assay Biologists.
• Ensure experiments and results are documented appropriately in laboratory notebooks and that processes are standardized and documented in SOPs that are rooted in industry standard practices.
• Assist to coordinate laboratory operations and standardize compound management practices at the company.Ideally, you have---
• A Ph.D. in Biology with a focus in Immunology, Neuroscience, Oncology, or a related field with post-doctoral plus 3+ years of experience at a high-growth biotechnology or pharmaceutical company.
• Experience with management of bench scientists.
• Experience in assay development, high-throughput screening, and automation of biological assays.
• Expertise in designing and executing screening test funnels to progress compounds from early drug discovery toward preclinical phases.
• Familiarity with preclinical drug development processes.
• Independence and adeptness in ambiguous situations, flexibility, and comfort in making decisions using minimal available data.
• A proven ability to work cross-functionally and adapt to changing priorities while managing multiple commitments with accuracy and efficiency to meet deadlines.Extremely generous equity package coupled with competitive salary.Excellent Healthcare benefits (employer covers 90% of insurance premiums).
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Keywords: 1910genetics, Boston , Scientist II, Assay Development and Screening, Other , Boston, Massachusetts