Chemical Engineering Senior Scientist

Company: Vertex Pharmaceuticals
Location: Boston
Posted on: March 25, 2025

Job Description:

Chemical Engineering Senior Scientist page is loadedChemical Engineering Senior ScientistApply locations Boston, MA time type Full time posted on Posted 10 Days Ago job requisition id REQ-24567Job DescriptionGeneral Summary:Vertex is seeking a talented individual to join the Engineering and Materials Science group in Boston, MA. Chemical Engineering at Vertex plays a vital role in bridging the gap between new pharmaceutical discoveries and commercial products for our synthetic molecule programs. Engineers at Vertex work in multidisciplinary scientific teams to bring medicines to patients and physicians by applying chemical engineering principles to new products and processes. A successful candidate will be a highly productive, results-oriented individual, able to generate and implement original ideas and solutions that contribute materially to the success and development of drug substance candidates. Strong communication, organization, and planning skills and a high level of technical aptitude and creativity are required for success in this position.Key Duties and Responsibilities:

• Apply engineering principles to design and optimize drug substance manufacturing processes for the synthesis and purification of small molecules, oligonucleotides, and synthetically-derived peptides using both established and novel technologies.
• Independently problem-solve in the laboratory setting to overcome synthetic, purification, and characterization challenges and develop/improve process workflows.
• Support drug substance process development via laboratory development, pilot plant scale-up, drug supply preparation, and technology transfer to contract manufacturing organizations.
• Manage relationships with external CRO/CMO partners.
• Independently develop creative solutions to overcome obstacles during development.
• Make use of state-of-the-art experimental, monitoring, and modeling approaches and/or data analyses for the evaluation and understanding of engineering unit operations -- including reactions, purification, and isolation technologies.
• Values teamwork and collaboration to solve problems and design strategies.Knowledge And Skills:
  • A successful applicant will have knowledge of peptide and oligonucleotide synthesis, optimization, and isolation. Hands-on experience with solid-phase automated synthesizers is preferred.
  • Experience developing and scaling-up solid phase and liquid phase chemistry and purification of resulting product streams. Familiarity with reversed phase chromatography, ion exchange chromatography, size exclusion chromatography and other purification techniques.
  • Familiarity with high-resolution mass spectrometry and other medium size molecule characterization techniques.
  • A demonstrated understanding and working knowledge of chemistry and chemical engineering fundamentals including applied kinetics, thermodynamics, and transport phenomena.
  • Knowledge and experience in synthetic drug substance process development, process scale-up, troubleshooting, and optimization.
  • Familiarity with statistical design of experiments, QbD concepts, and common physical property and process modeling tools.
  • Ability to successfully interact and collaborate within an interdisciplinary team environment comprised of organic chemists, analytical chemists, project team members, and manufacturing personnel.
  • Proven communication (verbal and written) and interpersonal skills.Education And Experience:
    • PhD in Chemical Engineering (or related field) and 2+ years of experience.
    • Master's Degree and 5+ years, or Bachelor's Degree and 8+ years of related experience.
    • Up to 15% travel, domestic and international.Pay Range:$123,200 - $184,700Disclosure Statement:The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.Flex Designation:On-Site DesignatedFlex Eligibility Status:In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.Company InformationVertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
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Keywords: Vertex Pharmaceuticals, Boston , Chemical Engineering Senior Scientist, Engineering , Boston, Massachusetts