Research Scientist II

Company: Aditi Consulting
Location: Lexington
Posted on: February 15, 2025

Job Description:

Payrate: $43.00 - $52.84/Hour

Remember to check your CV before applying Also, ensure you read through all the requirements related to this role.



Summary:

We are seeking a highly skilled and motivated Research Scientist - RNAi Formulations and Biophysics - to join our GNAT Research team. This lab-based role focuses on the formulation, biophysical, and analytical characterization of oligonucleotides for systemic delivery. The ideal candidate will have expertise in nucleic acid therapeutics and experience collaborating with external CMOs.



Job Responsibilities:

As a Sr Sci I in the Nucleic Acid Delivery, Formulations & Bioanalysis overall department, you will become a part of a multinational and diverse team consisting of Research Associates, Specialist/Scientists.
The goal of the team is to develop preclinical formulations of conjugated oligonucleotides apply advanced analytical characterization techniques and translate these to preclinical and clinical studies through internal and external collaborations in an automated high throughput manner.
Identifies gaps in technological capabilities provides recommendations to guide the research agenda
Manage multiple external collaborations for deliverables
Optimize long-term storage and stability conditions of RNAi conjugates and oligonucleotide formulations in general
Develop robust analytical methods and assays for QC and developability assessments
Communicate findings internally to team via presentations and written reports
Ability to thrive in a multi-disciplinary and fast-paced research environment with tight deadlines



Qualifications:

3 years of relevant experience with a PHD (LEVEL II) or 3+ years of relevant experience with a Masters (LEVEL I)
Subject matter expertise in Pharmaceutical Sciences, oligonucleotide/peptide/antibody characterization, or related scientific disciplines
In-depth and hands-on experience in a range of synthesis, characterization, and purification techniques, including but not limited to NMR, HPLC (analytical and preparative), Mass Spectrometry, IR, silica gel and reverse phase chromatography, TLC, recrystallization etc.
Acting as formulation subject matter expert for nucleic acid therapeutics.
Ability to establish screening assays for oligonucleotides in early discovery.
Experience with analytical method development for solubility, viscosity, degradation and rheological assessment for complex olionucleotides
Experience with high-throughput screening methods such as DoE for optimizing formulations is a plus
Excellent verbal communication and interpersonal skills
Demonstrate awareness of external trends, influences, and advances in the landscape of RNA delivery and clinical translation
Experience with automation is considered an advantage
Proven track record in publishing in HQ/HI journals on relevant topics.



Top Must-Haves:

Lab Experience: Expertise in formulation of siRNA or free oligonucleotides for systemic delivery.
Analytical Skills: Hands-on experience with analytical characterization of oligonucleotides.
Project Management: Proven ability to collaborate with and manage external CMOs.
Candidates with experience in formulating free oligonucleotides.
Alternatively, also looking for individuals with extensive experience in formulating proteins and peptides for QC and developability assessments.
Not need more chemists experience , need more formulators experience



Pay Transparency: The typical base pay for this role across the U.S. is: $43.00 - $52.84 per hour. Final offer amounts, within the base pay set forth above, are determined by factors including your relevant skills, education and experience and the benefits package you select. Full-time employees are eligible to select from different benefits packages. Packages may include medical, dental, and vision benefits, 10 paid days off, 401(k) plan participation, commuter benefits and life and disability insurance.



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Aditi Consulting LLC uses AI technology to engage candidates during the sourcing process. AI technology is used to gather data only and does not replace human-based decision making in employment decisions. By applying to this position, you agree to Aditi's use of AI technology including calls from an AI Voice Recruiter.

Keywords: Aditi Consulting, Boston , Research Scientist II, Other , Lexington, Massachusetts