Senior Associate Scientist, Translational Biomarker Discovery

Company: Disability Solutions
Location: Cambridge
Posted on: November 1, 2024

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: .When you join BMS, you are joining a diverse, high-achieving team united by a common mission. The Neuroscience TRC is committed to development of transformational therapeutics for patients with neurodegenerative and neuromuscular diseases. We have built a network of external partnerships across multiple treatment modalities (small molecules, biologics and RNA targeting) that leverage our leadership in protein homeostasis and inflammation to attack neurodegenerative, neuromuscular and neuropsychiatric diseases.Areas of interest include, but are not limited to, the following approaches:Disease modifying therapies for neurodegenerative, neuro-inflammatory and neuromuscular diseases; CNS targets that modulate protein homeostasis, protein clearance, inflammation and reduce or eliminate toxic protein production; Neuropsychiatric symptoms associated with neurodegenerative diseases; Emerging technologies (RNA targeting) that when matched to underlying disease genetics can deliver a precision medicine portfolio with a high probability of success to address unmet medical needs; Targets in neuromuscular diseases. Use approaches in cellular, preclinical and translational tools and technologies such as multiomics in tissue and fluid samples to identify novel biomarkers to track drug-target interactions and disease impact.Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.Position Summary: This is a lab-based position in the Cambridge, MA site and reports to the Principal Scientist, Translational Biomarker Development, Neuroscience. The Senior Associate Scientist will be part of the Neuroscience Thematic Research Center (Neuro-TRC) that leverages external collaborations and internal research to establish a diverse portfolio targeting unmet needs in neurodegenerative, neuroinflammatory, neuromuscular and neuropsychiatric diseases. Consistent with the overall Neuroscience TRC strategic model, the individual will design and deliver laboratory data to support the progression of drug candidates towards clinical proof-of-concept. To accomplish these tasks, the Senior Associate Scientist will work in the lab independently with guidance from the Principal Scientist and in collaborative efforts with other members of the Neuroscience TRC and BMS Research organization. In addition, the Senior Associate Scientist will support work with internal and external collaborators (CROs, academic laboratories, research consortia). The successful candidate will have a well-established track record of collaborative work in fast-paced, multidisciplinary research environment. In the role as a Senior Associate Scientist within the Neuroscience Translational Biomarker Development group, the ideal candidate will:

• Design and conduct experiments with guidance from the Principal Scientist to explore, develop and validate novel fluid and tissue-based biomarkers.
  • Perform ligand binding molecular assays, such as ELISA, Meso-scale discovery, SIMOA, etc. for biomarker assay development.
  • Perform and interpret qPCR, dd-PCR, RNAseq, etc. for support of biomarker development efforts.
  • Have hands-on experience with primary and iPSC cell culture, specifically neuronal and glial cultures systems.
    • In collaboration with Global Biospecimen Inventory Management, manage TRC specimens for target engagement and biomarker development.
    • Organize data and maintain thorough records via electronic laboratory notebook.
    • Prepare and present data and interpretations to manager and within BMS sub-team meetings and externally when feasible.
    • Develop/maintain knowledge of the current literature to understand novel concepts and targets.Basic Qualifications:
      • Bachelor's Degree
        • 4+ years of academic and / or industry experienceOr
          • Master's Degree
            • 2+ years of academic and / or industry experiencePreferred Qualifications:
              • BA/BS or equivalent advanced degree in the Life Sciences with specialization in neuroscience, cell and molecular biology, or similar and 4+ years of academic and / or industry experience, or MS in life sciences and 2+ years of academic and / or industry experience.
              • Embraces being highly accountable for timelines and deliverables.
              • Solid understanding of the principles of translational assay development with hands-on experience in immunoassay and molecular assay development (ELISA, Meso-scale discovery, SIMOA, qPCR, dd-PCR, RNAseq, etc.).
              • Hands-on experience with primary and iPSC cell culture, specifically neuronal and glial cultures systems.
              • Thorough understanding of immune modulatory approaches and experimental models, including FACS and flow cytometry.
              • Detailed knowledge and track record (as evidenced by publications in peer-reviewed journals) in principals of neuroscience, molecular biology,
              • Experience in managing biorepositories of preclinical and clinical samples (tissues, biofluids, etc).
              • Experience transferring assays to contract research organizations for analysis in multi-site clinical trials.
              • Excellent oral and written communication skills.
              • Organizational skills and record keeping.
              • Ability to work both independently and as a well-integrated member of multi-disciplinary drug development teams. If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as Transforming patients' lives through science--- , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site Protocol BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Disability Solutions, Boston , Senior Associate Scientist, Translational Biomarker Discovery, Other , Cambridge, Massachusetts