Associate Director, Biophysics

Company: Initial Therapeutics, Inc.
Location: Boston
Posted on: April 1, 2025

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionWe are seeking a highly skilled scientist with deep expertise in the application of biophysical methods in drug discovery to join the Structural Biology organization within Takeda's Global Biologics organization. The ideal candidate will possess a strong background in multiple biophysical techniques and apply this expertise towards understanding and optimizing small molecule-protein and protein-protein interactions as well as biologics developability. A successful candidate will contribute to multiple programs by generating results from internal and external (CRO-based) biophysics efforts and effectively collaborating with structural biologists, protein chemists, biophysics experts, project team members, and department management to advance Takeda's research pipeline.The successful candidate will:

• Serve as a subject matter expert for biophysics for Structural Biology and Global Biologics, applying knowledge and insights for small molecule binding and optimization, antigen activity validation, and biologics developability assessment.
• Design, execute, and analyze critical experiments using a variety of biophysical methods (SPR, ITC, DLS, DSF, etc.) with a high level of independence and collaboration to support hit validation, lead optimization, mechanism of inhibition studies, epitope mapping, biologic development tractability, and structural biology enablement for small molecule and/or biologics drug discovery.
• Collaborate and effectively communicate biophysical information and results to a variety of audiences in multiple settings including biophysical experts across departments, colleagues within Structural Biology and Global Biologics, diverse project teams, and department/research management.
• Maintain internal databases with the latest results and contribute to improvements to LIMS systems for biophysical data.
• Oversee activities at partner CROs producing biophysical data.Interested candidates should have:
  • PhD or equivalent experience in Biophysics, Biochemistry, Bioanalytical Chemistry, or a closely related field.
  • Minimum of 6+ years of laboratory experience in the pharmaceutical industry using biophysical methods to advance drug discovery programs and accelerate timelines; candidates with MS with 14+ or BS with 12+ years of experience are also considered.
  • Extensive knowledge and experience with varied biophysical techniques (SPR, DSF, DLS, ITC, MST, NMR, etc.).
  • Experience with both biologics and small molecule therapeutic molecules is highly desirable, including the application of biophysical techniques to biologics development.
  • Ability to work in a fast-paced, team-driven environment with a collaborative and proactive attitude; effectively communicate complex information to broad and varied audiences.
  • Experience with outsourcing and/or high-throughput automation systems is desirable.
  • A track record of innovation and scientific rigor across multiple protein targets and superfamilies, including challenging protein classes for biophysics (e.g., protein complexes, membrane proteins, targets with multiple substrates, etc.).Takeda Compensation and Benefits SummaryWe understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.For Location:Boston, MAU.S. Base Salary Range:$149,100.00 - $234,300.00The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.U.S.-based employees may be eligible for short-term and/or long-term incentives. U.S.-based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S.-based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.EEO StatementTakeda is proud of its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state, and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull timeJob ExemptYesIt is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
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Keywords: Initial Therapeutics, Inc., Boston , Associate Director, Biophysics, Executive , Boston, Massachusetts